Bile Acid Hydrogels for Controlled Release of Doxorubicin
Bile salts are a class of biological surfactants,which are synthesized in the liver for aiding lipids digestion in the small intestine 1.Unlike traditional surfactants,which typically have a hydrophilic head group bonded to a linear,flexible,and hydrocarbon tail,bile acids have a rigid and quasi-planar steroid backbone with polar hydroxyl groups on the hydrophilic α-face and methyl groups on the hydrophobic β-face,and a carboxyl group linked to the steroid backbone through a short alkyl chain.The facial amphiphilic structure of bile salts makes them unique building blocks for the assembly of one-dimensional (1D) supramolecular structures such as nanofibers,nanoribbons,and nanotubes 2-5.Under certain conditions,these 1D supramolecular structures are able to further entangle into three-dimensional (3D) networks,leading to the formation of hydrogels and organogels.
Wenlang Liang Jiyu Fang
College Of Materials Science and Engineering, Shenzhen University, Shenzhen, China Department Of Materials Science and Engineering, University Of Central Florida, USA
国际会议
The 12th International Symposium on Polymer Physics(PP’2016)(2016年第十二届国际高分子物理学术讨论会)
贵阳
英文
1-3
2016-06-10（万方平台首次上网日期，不代表论文的发表时间）