The Genetic Associations and Epistatic Effects of the CCR5 Promoter and CCR2-V64I Polymorphisms on Susceptibility to HIV-1 Infection in a Northern Han Chinese Population
The outcome of human immunodeficiency virus (HIV)-1 infection and course to AIDS are variable among indi-viduals.Both chemokine receptor 5 (CCR5) and CCR2 gene polymorphisms play essential roles in the susceptibility of HIV-1 infection.To investigate the main and epistatic effects of the CCR5 promoter and CCR2-V64I polymor-phisms on HIV-1 infection in the Northern Han Chinese, subjects of 91 HIV-l-infected patients and 91 health controls were recruited.Single-nucleotide polymorphisms (SNPs) in the CCR5 promoter region and CCR2-V64I variants were genotyped.In the single-locus analysis, CCR5 58755-G and CCR5 59653-T alleles were significantly associated with HIV-1 infection (odds ratio OR =0.529, 95% confidence interval CI: 0.295-0.948;OR =1.710, 95% C I: 1.039-2.814).After adjustment with age and gender, subjects with the CCR5 59653-CT genotype showed the increased risk of HIV-1 infection compared with those with the wild-type CC genotype (adjusted OR =2.502;95% CI:1.332-4.698).No positive association was observed in other SNPs.Haplotype-based association analysis revealed that the haplotype TATGC was associated with the susceptibility to HIV-1 infection (p =0.003).Besides, we found the significant epistatic effects between the CCR5 58755-A/G and CCR5 59029-A/G polymorphisms associated with the lower risk of HIV-1 infection.In addition, we also identified the best three-factor interaction model, including the CCR5 58755-A/G, 59029-A/G, and CCR2-V64I polymorphisms, indicating that there were also strong gene-gene interactions between the CCR5 promoter and CCR2 polymorphisms on the susceptibility of HIV-1 infection.These findings contribute to understanding the genetic mechanism for the susceptibility of HIV-1 infection in Northern Han Chinese.
Jiapeng Lu Aijuan Sheng Youxin Wang Ling Zhang Jingjing Wu Manshu Song Yan He Xinwei Yu Feifei Zhao Yezhou Liu Shuang Shao Jie Lan Hao Wu Wei Wang
School of Public Health and Family Medicine, Capital Medical University, Beijing, China;Municipal Ke Beijing YouAn Hospital, Capital Medical University, Beijing, China College of Life Science, University of Chinese Academy of Sciences, Beijing, China 5Systems and Inte Municipal Key Laboratory of Clinical Epidemiology, Beijing, China;College of Life Science, Universit
国际会议
北京
英文
104-120
2013-06-01（万方平台首次上网日期，不代表论文的发表时间）