Amorphous Cellulose Nanoparticles for Potential Long-circulation Drug Delivery
To overcome the side effects of free drug delivery and inconvenient continuous infusions, nanoparticle drug carriers have been developed to protect drugs and provide controlled and targeted drug delivery.However, the clearance of nanoparticles by the mononuclear phagocytic system (MPS) can hardly be avoided.To prolong the long-circulating time, it is important to develop nanoparticles which are invisible to the MPS.In this study,solid and hollow amorphous cellulose nanoparticles were developed through the phase separation method.The size, size distribution and the zeta potential of nanoparticles were measured at pH values ranging from 2 to 12.It was proven that the developed cellulose particles met the basic requirements for long-term circulation: hydrophilic, neutral in charge with a small size in the range from 70 nm to 200 nm and these particles (around 150 nm) were stable at temperatures ranging from-80 ℃ to 120 ℃.Therefore, the amorphous cellulose nanoparticles have great potential for the long-circulation drug delivery.
Long-circulation drug delivery system Nanoparticle Cellulose Amorphous
Lei Zu S.M.Kamrul Hasan Yiping Qiu Qiuran Jiang
Department of Technical Textiles, College of Textiles, Donghua University, Shanghai, P.R.China Key Laboratory of Textile Science & Technology, Ministry of Education, P.R.China;Shanghai Key Labora
国际会议
2015 Sino-Africa International Symposium on Textiles and Apparel(2015中非纺织服装国际论坛)
上海
英文
6-11
2015-05-29（万方平台首次上网日期，不代表论文的发表时间）