Allergen potential of non-prolamin seed proteins in Brachypodium distachyon
Prolamin proteins are considered key players in the development of wheat-related health problems,such as celiac disease or wheat allergy.However, there are further protein families that cause allergic responses.The relatively small number of expressed wheat seed proteins reported in the protein databases makes it difficult to get a complete overview of the allergome of wheat seed.Whole genome sequencing projects carried out on cereals such as wheat and barley will facilitate an understanding of the complex genetic effects of cereal allergies.Brachypodium distachyon serves as the evolutionary closest sequenced genome for the Triticeae.To better understand the potential detrimental effects of different seed proteins, an in-silico analysis was carried out using publicly available epitope databases and Brachypodium distachyon genome sequence data.This study summarizes our results in identifying potentially harmful non-prolamin proteins that may cause either celiac disease or wheat allergyrelated symptoms.
A.Juhász Gy.Gell E.Sebestyén R.Haraszi L.Tamás E.Balázs
Applied Genomics Department, Agricultural Institute, Centre for Agricultural Research, HAS, Martonvá Applied Genomics Department, Agricultural Institute, Centre for Agricultural Research, HAS, Martonvá Institute for Reference Materials and Measurements, European Commission Directorate General Joint Re Department of Plant Physiology and Molecular Plant Biology, E(o)tv(o)s Loránd University, Budapest,
国际会议
The 11th International Gluten Workshop(第十一届国际谷蛋白学术研讨会)
北京
英文
185-189
2012-08-12（万方平台首次上网日期，不代表论文的发表时间）