Training with Increased Intensities Benefits Post-stroke Rehabilitation Outcomes
Physical training is necessary for effective rehabilitation in the early post-stoke period.Many clinical and animal studies have been done to explore training protocols for more effective rehabilitation.Animal studies commonly use fixed training intensity throughout rehabilitation and without adapting it with their recovered motor ability.This study investigated the correlation between training intensity and rehabilitation efficacy by using a focal ischemic stroke rat model.Eighty male Sprague-Dawley rats were induced with middle cerebral artery occlusion/reperfusion surgery.Sixty rats with successful stroke were then randomly assigned into four groups: control(CG,n=15),low intensity (LG,n=15),gradually increased intensity (GIG,n=15) and high intensity (HG,n=15).Behavioral tests were conducted daily to evaluate motor function recovery.Stress level and neural recovery were evaluated via plasma corticosterone and brain-derived neurotrophic factor concentration,respectively.GIG rats significantly (P<0.05) recovered motor function and produced higher hippocampal BDNF (112.87±25.18) ng/g.GIG and LG rats exhibited similar stress levels(540.63±117.40) nmol/L and (508.07±161.30) nmol/L,respectively,which were significantly lower (P<0.05)than that (716.90±156.48) nmol/L of HG rats.Training with gradually increased intensity achieved better recovery with lower stress.Our observations indicate that a training protocol that includes gradually increasing training intensity should be considered in both animal and clinical studies for better stroke recovery.
ischemic stroke physical training stroke rehabilitation gradually training intensity
J.Sun J.Y.Feng K.Y.Tong
Department of Clinical Engineering, The First Affiliated Hospital, School of Medicine, Zhejiang Univ Interdisciplinary Division of Biomedical Engineering, The HK Polytechnic University, Hong Kong, Chin
国际会议
杭州
英文
41-46
2015-10-21（万方平台首次上网日期，不代表论文的发表时间）