Time-Effect Relationship of Toxicity Induced by Roundup(R) and Its Main Constituents in Liver of Carassius Auratus
In order to evaluate the eco-toxicological effects of Roundup(R) on Carassius auratus (C.auratus),fish were exposed to 32 μg/L Roundup(R),isopropylamine salt of glyphosate (G.I.S) and polyoxyethylene amine (POEA) over different periods (0.5,1,3,7 and 14 d).Hydroxyl radical (·OH),malondialdehyde (MDA) and acetylcholinesterase (AChE) in liver were detected in this study.Results showed that the generation of ·OH increased before 7 d,but without significantly difference.·OH was induced at 1 d for POEA group,3 d for Roundup(R) group and 7 d for G.I.S group.At 14 d,·OH generation returned to normal levels.MDA contents all increased significantly (p < 0.01) during 7 days and then reached a normal level at 14 d.AChE activity in all group tests revealed a significant inhibition (p < 0.01) after 7 days exposure and then rebounded a little,but remained below the control after 14 days exposure.The rate of AChE inhibition range from 13% - 42% in Roundup(R),6% - 40% in G.I.S,and 21% - 54% in POEA,suggesting that POEA was more toxic compared to Roundup(R) and G.I.S.32 μg/L Roundup(R) exposure led to the change of physiological and biochemical indexes in C.auratus,which was a reversible process in the long run.
Carassius Auratus Roundup(R) Hydroxyl Radical (·OH) Toxicity
Jinyu Fan Jinju Geng Hongqiang Ren Xiaorong Wang
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, China
国际会议
武汉
英文
20-25
2013-04-12（万方平台首次上网日期，不代表论文的发表时间）