Identification of Co-regulated Gene Network by Using Path Consistency Algorithm Based on Gene Ontology

摘要：

　　Recently, the reconstruction of co-regulated gene network has become increasingly popular in the area of bioinformatics.It tries to find the associated information and network topology among genes through large numbers of biological data.In this paper, we proposed a novel method PC-GO by using path consistency (PC) algorithm based on gene ontology (GO).GO provides a basis for measuring the conditional semantic similarity between genes, and then PC algorithm is applied to remove links between genes with less correlation in the network.We successfully applied our algorithm to yeast data.Experimental results show that the accuracy and integrity of the co-regulated network acquired by our method outperforms previous methods.

关键词： Gene ontology conditional semantic similarity path consistency algorithm co-regulated gene network

作者: Hanshi Wang Chenxiao Wang Lizhen Liu Chao Du Jingli Lu

作者单位: Information and Engineering College, Capital Normal University, Beijing, China Agresearch Ltd, Hamilton, New Zealand

会议类型: 国际会议

会议名称: 8th International Conference on Intelligent Information Processing(2014年IFIP智能信息处理国际会议)

会议地点: 杭州

会议语种:英文

页码: 278-283

在线出版日期: 2014-10-01（万方平台首次上网日期，不代表论文的发表时间）