Using Functional Near-infrared Spectroscopy to Investigate Frontal Cortical Response to Joint/non-joint Attention in Children
Functional near-infrared spectroscopy (fNIRS) is an optical technique for non-invasively investigating brain functional activity. It measures cerebral hemodynamic parameters that are closely associated with the neural activity. Previous study has demonstrated that individuals with autism are very poor in joint attention skills. In this work, fNIRS was used to access cerebral hemodynamic response to joint and non-joint attention stimuli in children classified as of high and low autistic traits. The stimuli were given by a video that engenders an experience of joint or non-joint attention in observers. 49 channels of oxygenated hemoglobin (HBO) time series were recorded from the frontal cortex when subjects were watching the video. The HBO activation pattern was obtained and the functional connectivity was determined for the two conditions. Results show there are significant differences between children with high and low autistic traits, in both the HBO response and the functional connectivity for each condition. Our data suggest that fNIRS may provide imaging-based objective evaluation on autistic traits.
Jun Li Zhifang Zhu Huilin Zhu
Centre for Optical and Electromagnetic Research South China Normal University, Guangzhou 510006, China
国际会议
Progress in Electromagnetics Research Symposium 2014(2014年电磁学研究新进展学术研讨会)
广州
英文
2235-2239
2014-08-01（万方平台首次上网日期，不代表论文的发表时间）