Randomized trial of repetitive transcranial magnetic stimulation for apathy and depression in Parkinsons disease
Background: Repetitive transcranial magnetic stimulation(rTMS)has been reported toimprove depression in Parkinsons disease(PD)patients,but there has been only onerandomized controlled trial.Methods: Fifteen PD patients received real rTMS(5 Hz,500 pulses/day)and placebostimulation over the supplementary motor area(SMA)for 5 days,using a randomizedreal-first or placebo-first protocol.The modified apathy scale,the Zung Self-ratingDepression Scale(SDS)and Unified Parkinsons Disease Rating Scale(UPDRS)wereused to assess apathy,depression and clinical status before and after each treatmentResults: Real rTMS improved the apathy score by 3 points(P<0.05)compared to thebaseline,while placebo stimulation produced no improvement,irrespective of the orderof treatment.Real rTMS also improved the depression scale,SDS by 5 points(P<0.05)compared to the baseline,while placebo stimulation was ineffective.Combined analysisconfirmed that real rTMS was significantly superior to placebo stimulation in apathyand depression(p<0.05).Real rTMS also improved UPDRS by 10 points(P=O.O01),while placebo stimulation was ineffective.Conclusions: rTMS over the SMA appears to be effective for treatment of apathy anddepression in PD patients.
Apathy rTMS Parkinsons disease depression UPDRS
Hiroaki Oguro Tomonori Nakagawa Shingo Mitaki Masaki Ishihara Keiichi Onoda Shuhei Yamaguchi
Department of Neurology,Faculty of Medicine,Shimane University,Shimane,Japan
国际会议
The 2014 ICME International Conference on Complex Medical Engineering (CME2014)ICME复合医学工程国际会议
台北
英文
22-35
2014-06-26（万方平台首次上网日期，不代表论文的发表时间）