Simultaneous Measurement of Local Brain Temperature and Cerebral Blood Flow Change in Rats for Quantitative Functional Brain Imaging
Neuronal activity locally leads to increase in oxygen and glucose metabolism(Neuro-metabolic coupling)which leads to increase in cerebral blood flow(Neuro-vascular coupling).The metabolic activity generates heat and increases local brain temperature.As a result,the change of brain temperature by neural activity is possibly a more direct indicator of brain function than that of cerebral blood flow.In order to develop a brain temperature imaging technique so we can evaluate the brain activity quantitatively,we measured local brain temperature changes in rats using an infrared camera which has not only high spatiotemporal resolution,but also high temperature resolution(0.018K).We reported that the brain temperature significantly increases about 0.05K following a rat whisker stimulation(Suzuki et al.,J Appl Physiol.2012).However,local brain temperature change following neural activity depends on a balance between heat generation and heat convection.In fact,we found that temperature change first appeared around the middle cerebral artery.From the result,there is still a problem that local change in brain temperature can be also affected by the effect of cerebral blood flow change.
Infrared Brain temperature Cerebral blood flow Imaging
Takashi Suzuki Naoya Oishi Hidenao Fukuyama
Human Brain Research Center Department of School of Medicine,Kyoto University Kyoto,Japan 606-8507
国际会议
The 2014 ICME International Conference on Complex Medical Engineering (CME2014)ICME复合医学工程国际会议
台北
英文
214-219
2014-06-26（万方平台首次上网日期，不代表论文的发表时间）