Prototyping System of Cell Separation Based on Microfluidic Chip
Different biomedical particle separation is a key point in the field of biomedicine.It is very important to separate the target cell quickly and correctly for early diagnosis,treatment and prevention of disease.Taking microfluidic chip as the experiment platform,the separation methods was investigated in this paper.Firstly,the methods on biological particles separation were reviewed briefly.And the advantages and shortcomings of the methods were analyzed.After confirming the microchannel structure of microfluidic chip,the injecting structure was optimized by simulating the regulation of liquid in microchannel.The microfluidic ship was made based on the theoretical analysis.Secondly,in order to ensure the separation effect and decrease the size of the instrument,Ion-exchange Polymer Metal Composite,IPMC,was used to driving the liquid in microchannel to separate particles.The main advantages of IPMC are quick response speed,high deformation variable,and good elasticity.They are benefit to separate the particles.The driving condition of IPCM was theoretical analyzed to ensure the separating effect.According to the signal features and transmission rate,the data acquisition circuit was designed by PADS to detect the fluorescence signal.And the related programs with the functions of collection,storage,playingback,displaying and user interfaces were also set up.Eventually,taking the labeled polystyrene beads to mimic the cells,a serial of experiments were performed to verify the function of IPMC.The experiment results showed that the biological particle separation system based on microfluidic chip could separate the particles successfully.
Microfluidic chip Simulation IPMC Separation system
Qin Li Xiaoming Hu Haiyang Qian Yingying Zhao Xiuzhen Li
Department of Biomedical Engineering Beijing Institute of Technology Beijing,100081,P.R.China
国际会议
The 2014 ICME International Conference on Complex Medical Engineering (CME2014)ICME复合医学工程国际会议
台北
英文
308-308
2014-06-26（万方平台首次上网日期，不代表论文的发表时间）