Qualitative Modeling and Analysis of the Indoleamine 2,3-dioxygenase Regulatory Network in Homeostasis and Disease
Indoleamine 2,3-dioxygenase(IDO)has key role in immune regulation and it acts as a constituent of the inflammatory reaction allied with infection,allergic diseases,autoimmunity and cancer.IDO function as an immunosuppressive enzyme,which degrades the tryptophan into kynurenine and other downstream metabolites.Interferon gamma(IFN-γ)is a potent inducer of IDO.Transforming growth factor-beta(TGF-β)is the negative regulator of IDO.Both the TGF-β and IFN-γ have opposite effects on various cellular functions.IFN-γ and TGF-β inhibit the activity of each other through different pathways.In the pathological state when the homeostasis disturb,the impairment of IDO provides significant role in the pathogenesis of disease.The modeling of the gene regulatory network of IDO,IFN-γ and TGF-β using of René Thomas Formalism,help us in understanding their dynamical behaviors.We observe two types of steady states behaviors in this study.The cycle shows the homeostasis of IDO and TGF-β while IFN-γ is inactive(silent).The stable state shows the high expression levels of IFN-γ and IDO while TGF-β is silent.These findings recognized prospective novel targets for therapy in a range of clinical conditions,including,inflammation,tumor resistance and autoimmunity.
IDO TGF-β IFN-γ gene regulatory network
Kashif Asghar Jamil Ahmed Javaria Ashraf Amjad Ali Hussnain Ahmed Janjua S.Murad
Atta-ur-Rehman School of Applied Biosciences,National University of Science & Technology,NUST,Islama Research Center for Modeling & Simulation,National University of Science & Technology,NUST,Islamabad
国际会议
厦门
英文
517-521
2014-08-19（万方平台首次上网日期，不代表论文的发表时间）