Dynamics analysis of an amended HBV infection model with a simulation for anti-HBV infection therapy
This paper introduces an amended hepatitis B virus(HBV)infection model with an immune response term and an alanine aminotransferase(ALT)term.It has been proved that if a basic virus reproductive number R0<1,then the virus free equilibrium point of the model is globally asymptotically stable; if R0>1,then the immune depletion equilibrium point of the model is globally asymptotically stable.This result implies that if an HBV infected patient has R0<1,then the patient will eventually recover even if infected with a large amount of virus.Simulating the dynamics of evolutions of serum HBV DNA levels and ALT levels for 115 Asians and 113 non-Asians HBeAg positive chronic hepatitis B(CHB)patients Tenofovir Disoproxil Fumarate(TDF)48 weeks therapy reported by C.Pan et al.,the results show that TDF anti-HBV infection therapy may not only suppress the HBV DNA levels via destructing patients infected hepatocytes but also activate patients ability of cytokine-midiated non-cytolytic HBV clearance,which clears HBV directly without damaging patients hepatocytes.
HBV infection model Basic virus reproductive number Globally asymptotically stable Anti-HBV infection therapy Numerical simulation
CHEN Xiao SUN Kaiyun QIU Jianlong CHEN Xiangyong YANG Chengdong ZHANG Ancai
School of Informatics,Linyi University,Linyi 276005,P.R.China School of Mathematical Sciences,Shandong Normal University,Jinan 250358,P.R.China;School of Sciences School of Sciences,Linyi University,Linyi 276005,P.R.China;Department of Electrical and Computer Eng School of Sciences,Linyi University,Linyi 276005,P.R.China School of Automobile Engineering,Linyi University,Linyi 276005,P.R.China
国际会议
The 33th Chinese Control Conference第33届中国控制会议
南京
英文
2829-2834
2014-07-28（万方平台首次上网日期，不代表论文的发表时间）