A Pharmacokinetic Study of Caffeine Transdermal Therapeutic Systems

摘要：

　　Pharmacological properties of caffeine transdermal therapeutic systems (TTS) were studied.It was demonstrated that the developed TTS matrix a chieves diffusion of the drug substance through the in tact skin, ensuring a constant drug concentration in the blood for a prolonged time period (up to 27 hours).It was shown that caffeine bioavailability increased 2.5 times in the case of transdermal administration as com pared to the conventional routes of drug administra tion.Also, the elimination half-life and the mean resi dence time during application of investigated TTS are higher in comparison with traditional drug forms.

关键词： caffeine pharmacokinetics trans dermal therapeutic systems

作者: Y.B.Basok L.A.Salomatina A.A.Tikhobaeva V.I.Sevastianov

作者单位: The Shumakov Federal Research Center of Transplantology and Artificial Organs Shchukinskaya 1,Moscow,Russia,123182 ;Institute of Biomedical Research and Technology (ANO),B. Tishinsky,43/20,building 2,Moscow,Russia,123557

会议类型: 国际会议

会议名称: The 12th China-Russia Symposium on Advanced Materials and Technologies(第十二届中俄双边新材料新工艺国际会议)

会议地点: 昆明

会议语种:英文

页码: 175-177

在线出版日期: 2013-11-19（万方平台首次上网日期，不代表论文的发表时间）