A Novel Antitumor Drug-loaded Biodegradable Stent for the Treatment of Colorectal Cancer
The paper presents a novel biodegradable weft-knitted stent composing double layers witii drug delivery function,which can be used for treatment of colorectal cancer.The inner layer is a tubular weft-knitted graft made from polydioxanone yarn.The outer layer is a drug-loaded electro-spun membrane.The mechanical results showed that tiie radial force of stent can reach above 3.3 cN/cm2 under compression at 50%.This value is better than commercial Wall-stent and Z-stent from market.The drug-loaded membrane was examined by SEM,FTIR and HPLC to examine the morphology,chemical structure,drug loaded efficiency and release property in vilro.The results revealed that 5-FU as the loaded drug is distributed evenly in the eleclro-spun membranes.The HPLC results revealed tiiat tiie released amount of 5-FU was greatly elevated when 5-FU-loaded percentage increased.The release mechanism was divided into two stages,i.e.a fast release profile in tiie 24 hours,and then a stable release pattern maintained.It can be suggested that proper drug concentration,fiber diameter and evenness of tiie drug-loaded PLLA fibrous membrane are very important for drug release profile.In conclusion,this drug-loaded stent may find promising clinical applications for colorectal cancer in the future.
Biodegradable weft-knitted stents Drug-loaded Electro-spun membrane Mechanical properties Drug release
Gang Li Yi Li Ping Lan Jia-Shen Li Hong Hu Wen-Zu Wang Yu-Ling Li Jun-Yan Hu
Institute of Textiles and Clothing,The Hong Kong Polytechnic University,Hung Hom,Kowloon,Hong Kong;G Guangdong-HK International Textile Bioengineering Joint Research Center,The Hong Kong Polytechnic Un Institute of Textiles and Clothing,The Hong Kong Polytechnic University,Hung Hom,Kowloon,Hong Kong College of Textiles,Donghua University,201620,China
国际会议
第六届纺织生物工程及信息国际会议(The 6th Textile Bioengineering and Informatics Symposium )(TBIS2013)
西安
英文
200-208
2013-09-26（万方平台首次上网日期，不代表论文的发表时间）