Observations of Skin Tissue Regenerations in Biomaterial Scaffolds with Different Biodegradability
Objective: To explore the effects of the biodegradability of biomaterial scaffolds on skin tissue regeneration and its neovascularization by the animal experiments.Methods: A piece of porous silk fibroin film (SF) of easy biodegradation and a piece of porous polyvinyl alcohol film (PVA) of hard biodegradation were implanted into a same skin wound of adult rat, and the differences in the regenerative blood vessel and tissue at 5, 10, 16, 41 days after surgery were observed by histological methods.Results: (1) at 10 days after surgery, the SF started to degrade, the closed areas without cell infiltration were opened up and the entire material was filled with the regenerative tissue, and there were still the closed areas in the PVA, (2) the new vascular network remodeling in the SF and PVA appeared at 10 days and 41 days after surgery, respectively, and (3) at 16 days after surgery, most of the SF material had degraded and substantially been replaced with the regenerative tissue, and the visible degradation of the PVA appeared at 41 days after surgery.Conclusion: The good biodegradability of the SF was helpful both to all vascularization of the material and to the regenerative blood vessels remodeling, and the regenerative tissue was closer to the normal dermal tissue than in the PVA.
Silk fibroin Polyvinyl alcohol Neovascularization Immunohistochemistry Tissue regeneration
Kuihua Zhan Liang Xie Xinhong Wang Baoqi ZUO Lun Bai
School of Mechanical and Electronic Engineering,Soochow University,178 Ganjiang East Road,Suzhou,215 Department of Orthopaedics,The Second Affiliated Hospital of Soochow University,1055 Sanxiang Road,S College of Textile and Clothing Engineering,Soochow University,178 Ganjiang East Road,Suzhou,215006,
国际会议
苏州
英文
79-82
2013-09-09（万方平台首次上网日期，不代表论文的发表时间）