Controlled release behaviors of ketoprofen from matrix polymer of chitosan and poly(ethylene glycol)

摘要：

　　The aim of present work was to prepare floating microsphere of ketoprofen using matrix polymer of chitosan and poly(ethylene glycol) by solvent diffusion method.The floating microsphere of ketoprofen was prepared from matrix polymer of chitosan and poly(ethylene glycol) with various composition ratios and evaluated such as particle size, drug compatibility and drug release of microspheres.The scanning electron microscopy of microspheres confirmed their hollow structures with smooth surface.Formulation CPK 4 to CPK 6 exhibited the best controlled release pattern in ketoprofen.The concentration and size of poly(ethylene-glycol) affected the particle size, percentage yield and drug release of microspheres.

关键词： Ketoprofen Chitosan Poly(ethylene glycol)

作者: Thitiphan Chimsook

作者单位: Department of Chemistry,Faculty of Science,Maejo University,Chiang Mai,Thailand

会议类型: 国际会议

会议名称: the 2013 2nd International Conference on Metallurgy Technology and Materials(ICMTM2013)(第二届冶金技术与材料国际会议)

会议地点: 香港

会议语种:英文

页码: 399-402

在线出版日期: 2013-06-25（万方平台首次上网日期，不代表论文的发表时间）