Data Reconciliation of Release Mechanism Research of LDH-Based Drug

摘要：

　　Sebacate pillared layered double hydroxides (LDH) was prepared via co-precipitation method.And then the drug 10-hydroxy-camptothecin (10-HC) was intercalated into the gallery of LDH to form the drug-LDH composites.Three types of dissolution-diffusion kinetics models were used to make clear the drug release mechanism of the LDH composites.For the first time data reconciliation was used to make clear the drug release kinetics mechanism of the LDH composites, which was carried out by using a data filter algorithm based on first-order delay filter and time-delay principle to diminish random experimental errors resulting from the factors including stirring speed, solid content, and so on.Simulation results indicated that the data reconciliation adequately degraded the interactions between drug release rates at different times and made the data satisfy the kinetics models for the drug release mechanism more accurately.

关键词： 10-HC LDH Release mechanism Data reconciliation Data filter

作者: Xiaoxia Liu

作者单位: Information Technology Department of Qingdao Vocational & Technical College of Hotel Management, Qingdao, Shandong, China, 266100

会议类型: 国际会议

会议名称: 4th international Conference,ICSI2013(第4届群体智能国际会议)

会议地点: 哈尔滨

会议语种:英文

页码: 524-530

在线出版日期: 2013-06-12（万方平台首次上网日期，不代表论文的发表时间）