Difference of Audiovisual Integration between Alzheimer’s Disease Patients and Age-matched Healthy Controls:An fMRI Study
Alzheimer’s Disease (AD) is the most common and destructive neurodegenerative disorder threatening old people.As a non-invasive way to assess brain function,the fMRI technique can be used to detect how the brain activity pattern of AD patients differ from that of age-matched elder controls (EC).We compared the brain activity pattern of AD and EC under three conditions: unimodal auditory stimuli,unimodal visual stimuli and bimodal audiovisual stimuli.It was found that patients with AD exhibit a more extensive but relatively weaker response than EC,and in every type of stimuli,the activated brain areas are dissimilar with EC.The limbic lobe of AD patients is universally silent while the hippocampal areas in EC are active.Moreover,compared with EC,AD patients show fewer activated regions for audiovisual integration,indicating impaired multisensory information processing and cognitive integration.The findings imply that fMRI can help with the diagnosis of AD even in the early stage.
Alzheimer’s Disease Functional Magnetic Resonance Imaging Audiovisual Integration
Lu Yang Jiajia Yang Naoya Nakamura Jinglong Wu Seiichiro Ohno Tomoko Kurata Koji Abe Susumu Kanazawa
School of Life Sciences Peking University Yiheyuan Road 5th, Beijing, 100871 Biomedical Engineering Laboratory, Graduate School of Natural Science and Technology Okayama Univers Department of Radiology, Okayama University Hospital Okayama University 2-5-1, Shikata-cho, Okayama Graduate School of Medicine, Dentistry, Pharmaceutical Sciences Okayama Univerisity 3-1-1 Tsushima-n
国际会议
2013 ICME International Conference on Complex Medical Engineering(2013 ICME复合医学工程国际会议)
北京
英文
19-24
2013-05-25（万方平台首次上网日期，不代表论文的发表时间）