Tensor-based Analysis for Measuring Ventricular Volume Increases in Mouse Brain MR Microscopy

摘要：

　　This paper describes a method for detecting small ventricular volume differences between experimental group and non-drug using control group in mouse brain.Deformations are obtained by a three step intensity-based nonlinear registration routine that transforms one brain to another.High resolution T2-weighted mouse brain magnetic resonance microscopy (MRM) was analyzed using full deformation tensor.A significant mean Jacobian determinant increase was found in the experimental group (0.151±0.029,p<0.001,two-tailed t-test) but not in the control group (0.021±0.027,p=0.07).Moreover,the increase in mean ventricular Jacobian determinant in the experimental group is significantly greater than in the control group (p<0.001).This approach may be used to investigate the increasing in ventricular volume in transgenic mice and other putative animal models of Alzheimer’s disease.

关键词： ROIs Jacobian determinant image registration mouse model

作者: Lan Lin Guangyu Bin Xiaoting Xu Shuicai Wu

作者单位: College of Life Science and Bioengineering Beijing University of Technology Beijing, 100124, China

会议类型: 国际会议

会议名称: 2013 ICME International Conference on Complex Medical Engineering(2013 ICME复合医学工程国际会议)

会议地点: 北京

会议语种:英文

页码: 50-53

在线出版日期: 2013-05-25（万方平台首次上网日期，不代表论文的发表时间）