Fragmentation Pattern of Glycated Peptides Derived from D-glucose by Tandem Mass Spectrometry

摘要：

　　Evidence shows that non-enzymatic glycation plays an important role in the development of diabetes,diabetes-related complications and neurodegenerative diseases.Mass spectrometric methods have been used for non-enzymatic glycation of proteins.At present,CID remains the major fragmentation method for peptide sequencing.In this study,we utilized synthesized peptide models to study fragmentation spectra of glycated peptides,which can be easily studied using ESI-MS.MS/MS fragmentation whose characteristics of glycated peptides will help for large-scale glycated proteomics analyses of complex plasma and tissue samples.

关键词： Non-enzymatic glycation Fragmentation CID neutral loss

作者: Rui Su Yahui Liu Yun Wang Yongqian zhang Qing Hong Yulin Deng

作者单位: School of Life Science and Technology, Beijing Institute of Technology, 100081 Beijing China

会议类型: 国际会议

会议名称: 2013 ICME International Conference on Complex Medical Engineering(2013 ICME复合医学工程国际会议)

会议地点: 北京

会议语种:英文

页码: 493-496

在线出版日期: 2013-05-25（万方平台首次上网日期，不代表论文的发表时间）