Screening Human Epidermal Growth Factor Receptor-2 Inhibitors From Natural Products

摘要：

　　Using the technology of molecular docking,the inhibitor structural features of human epidermal growth factor receptor-2 were studied by screening human epidermal growth factor receptor-2 inhibitors from natural products databases.DS virtual screening systems had been established.The extracellular region and kinase domain of HER2 were selected as target protein.Different conformations,interaction forces formed and important amino acids were discussed in the docking process.The result indicated that the extracellular region of HER2 was prone to combine steroids with oligosaccharide chain and the kinase domain of HER2 easily combined compounds with more oxygen atoms and unsaturated bond.

关键词： Human epidermal growth factor receptor-2 Natural products database Molecular docking

作者: Xiujie Liu Shaohua Jia Rongji Dai Yulin Deng Fang Lv

作者单位: School of Life Science, Beijing Institute of Technology, Beijing 100081, China

会议类型: 国际会议

会议名称: 2013 ICME International Conference on Complex Medical Engineering(2013 ICME复合医学工程国际会议)

会议地点: 北京

会议语种:英文

页码: 497-500

在线出版日期: 2013-05-25（万方平台首次上网日期，不代表论文的发表时间）