Study of PNIPAAm-PEG thermo-sensitive copolymer micelle and application as drug carrier for icariin

摘要：

　　A series of thermally responsive copolymers PNIPAAm-PEG were prepared through RAFT polymerization.Their molecular structures were verified by 1H NMR spectroscopy and GPC.The temperature-dependent characteristics study has revealed that PNIPAAm- PEG exhibits a lower critical solution temperature (LCST) of about 34~42°C with the PNIPAAm:PEG molecular weight ratio of 1:1 to 10:1.When PNIPAAm:PEG=1.8:1,the polymer has a LCST of 37.8°C,which is very close to body temperature.The micelles also showed nearly 85% encapsulation efficiency for icariin with temperature dependent release.These results indicate that PNIPAAm-PEG is a promising drug carrier for icariin,and icariin- PNIPAAm-PEG has great potential in bone defect and disease treatment.

关键词： thermo-sensitive PNIPAAm PEG icariin

作者: Xiaoyan Xu Taotao Liu Enke Feng Wen Zhang Yan Li Jun Zheng

作者单位: School of Materials Science and Engineering, Tongji University, Shanghai 201804, China; Key Laborato School of Materials Science and Engineering, Tongji University, Shanghai 201804, China Shanghai University of Traditional Chinese Medicine, Yueyang Hospital of Integrated Chinese and West

会议类型: 国际会议

会议名称: 2013 ICME International Conference on Complex Medical Engineering(2013 ICME复合医学工程国际会议)

会议地点: 北京

会议语种:英文

页码: 523-527

在线出版日期: 2013-05-25（万方平台首次上网日期，不代表论文的发表时间）