A Theoretical Ultrafiltration Model for Albumin- Bound Toxin Dialysis

摘要：

　　A theoretical mass transfer model considering the local ultrafiltration across the hollow fiber membrane during the dialysis process of albumin-bound toxins is presented in this paper.Then,this model is compared in detail with the model in the literature,which does not consider the local ultrafiltration when the net ultrafiltration is zero and assumes the local ultrafiltration to be a constant when the net ultrafiltration is not zero.The results show that relatively,the accuracy of the literature model is limited because it neglects the effect of the linear decreasing local ultrafiltration on the toxin transport across the membrane no matter whether the net ultrafiltration is zero.Compared to the model in this study,the literature model always overestimates or underestimates the clearance of toxins,especially when the net ultrafiltration is not zero.The model in this study can be used to accurately predict the clearance of albumin-bound toxins and thereby optimize the dialysis process in artificial liver support systems.

关键词： albumin dialysis local ultrafiltration hollow fiber membrane toxin artificial liver support system

作者: Yingying Pei Yize Sun Yang Xu Gang Zhao Dayong Gao Weiping Ding

作者单位: Department of Mechanical Engineering Donghua University Shanghai, China Department of Electronic Science and Technology University of Science and Technology of China Hefei,

会议类型: 国际会议

会议名称: 2013 ICME International Conference on Complex Medical Engineering(2013 ICME复合医学工程国际会议)

会议地点: 北京

会议语种:英文

页码: 528-531

在线出版日期: 2013-05-25（万方平台首次上网日期，不代表论文的发表时间）