A Review on Research of the Sustained Release Drug Delivery System Based on Magnesium Aluminate Layered Double Hydroxide
This paper reviewed our research progress in respects of th intercalation law of acetylsalicylic acid (ASP) with magnesium aluminate layered double hydroxide (LDH), the drug release mechanism and the tablet preparation effect of LDH-ASP system.We also discussed the propositions about the composite assembly rules, slow-release mechanism, and dosage form processing of the layered double hydroxide drug delivery system.Intercalation way and drug structure should be taken into consideration in assembly LDH-drugs system.The characteristic parameter of the composite LDH-drug reflected finely their loading efficiency and correlated defmitely with drug release property.It had been found that the release rate and extent of intercalated drug was closely linked to the retarding status of LDH interlayer, which was dependent on the exchange mole ratio of n(drug) with nHnPO4(3-n)-.In addition, the grafting reaction and phase transformation degree of LDH layer was hinged on the acidity of solution.The slow-release function of the LDH-drug system could be improved significantly by compositing with dextran (DET).A sustained-release skeleton tablet was producted with DET-LDH-ASP drug delivery system and hydrophilic gel material HPMC, which could effectively overcome the first pass effect and burst release problem of LDH-drug oral agents.The slow-release effect of LDH drug delivery system could be ulteriorly improved in systemic circulation environments, attributed to the triple control of HPMC-DET-LDH, DET-LDH-drugs three-level supramolecular assembly and the special circulation in vivo.
Layered double hydroxide Supramolecular assembly Release control Slow controlled release drug delivery system
Guo-jing GOU Li-e DONG Feng-juan Bao Zhi-Yu WANG Lin JIAO Jie HUANG Yue SUN Bing XUE
Medical chemistry department,School of Basic Medical,Ningxia medical university,yinchuan 750004
国际会议
2012 China Functional Materials Technology and Industry Forum(2012中国功能材料科技与产业高层论坛)(CFMTIF2012)
昆明
英文
495-504
2012-11-09（万方平台首次上网日期，不代表论文的发表时间）