Synthesis and cytotoxic activity of salicyloyl hydrazone derivatives

摘要：

　　Three salicyloyl hydrazone derivatives (compounds 1-3) were prepared by reacting salicyloyl hydrazine with substituted formaldehydes.Their structures were characterized by melting point, 1H-NMR, ESI-MS and elemental analyses.The cytotoxic activity of compounds 1-3 was evaluated in vitro against Hela cells (human cervical cancer cells).The results revealed that all the compounds showed cytotoxic activity, with IC50 values lower than 15 μM.

关键词： salicyloyl hydrazone derivatives cytotoxic activity structure-activity relationships

作者: Xiaoyang Qiu An-Ran Shi Xiaoli Zhang

作者单位: Department of Chemistry,Shangqiu Normal College,Shangqiu 476000,China College of Chemistry and Chemical Engineering,Nanjing University of Science and Technology,Nanjing 2

会议类型: 国际会议

会议名称: 2012 China Functional Materials Technology and Industry Forum(2012中国功能材料科技与产业高层论坛)(CFMTIF2012)

会议地点: 昆明

会议语种:英文

页码: 522-525

在线出版日期: 2012-11-09（万方平台首次上网日期，不代表论文的发表时间）