Study on Cytotoxicity of Dextran-Magnetic Layered Double Hydroxide-Fluorouracil Targeted Liposomes in vitro

摘要：

　　This paper studied the cytotoxicity of the dextran-magnetic layered double hydroxide-fluorouracil targeted liposomes (DET-MLDH-FU liposomes, DMFL) by MTT method against human ovarian adenocarcinoma cancer cells (SKOV3) in vitro.The results shown that the cellular inhibition rate at 24 h increased with the increasing of the fluorouracil concentration in DMFL, DET-MLDH-FU (DMF), fluorouracil-loaded liposomes (FUL) and free fluorouracil (FU).The order of inhibition rate was DMFL, DMF, FUL and FU at same concentration and intervention time.The IC50 values of DMFL, DMF, FUL and FU were 14.39, 25.47, 34.39, 48.71 (μg·mL-1), respectively.The results of cytotoxicity experiment proved that the DMFL was superior than other preparations of fluorouracil.

关键词： Dextran-magnetic layered double hydroxide-fluorouracil targeted liposomes Cytotoxicity Inhibition rate

作者: Jie Huang Bin Xue Guo-jing Gou

作者单位: Medical chemistry department,School of Basic Medical,Ningxia medical university,yinchuan 750004

会议类型: 国际会议

会议名称: 2012 China Functional Materials Technology and Industry Forum(2012中国功能材料科技与产业高层论坛)(CFMTIF2012)

会议地点: 昆明

会议语种:英文

页码: 526-528

在线出版日期: 2012-11-09（万方平台首次上网日期，不代表论文的发表时间）