Intracellular Trafficking Characteristics for Magnetic Layered Double Hydroxide/DNA Hybrids to Human Gastric Cancer Cells

摘要：

　　We report here the intracellular trafficking characteristics of a gene delivery system composed by magnetic layered double hydroxide/DNA (MLDH/DNA) hybrids to human gastric cancer cells (SGC-7901).Perls Staining of MLDH/DNA was done to examine the intracellular iron uptake and accumulation; confocal microscopy and transmission electron microscopy were evaluated the cellular internalization feature of the MLDH/DNA system.We have indicated that the MLDH/DNA hybrids are able to enter into the nucleus within 2 h of incubation, displaying a prospect for application in targeted gene delivery.

关键词： Magnetic layered double hydroxide/DNA hybrids Intracellular trafficking Gene delivery

作者: Yue Sun Guojing GOU Li-e Dong

作者单位: Department of Chemistry,Ningxia Medical University,Yinchuan 750004,China;Research Center of Medical Science and Technology,Ningxia Medical University,Yinchuan 750004,China

会议类型: 国际会议

会议名称: 2012 China Functional Materials Technology and Industry Forum(2012中国功能材料科技与产业高层论坛)(CFMTIF2012)

会议地点: 昆明

会议语种:英文

页码: 529-532

在线出版日期: 2012-11-09（万方平台首次上网日期，不代表论文的发表时间）