Facile synthesis of(R)-1-(1H-indol-3-yl)propan-2-amines hydrochloride from Ketones

摘要：

　　Two kinds of (R)-1-(1 H-indol-3-yl)propan-2-amines were prepared through a five-step sequence procedure.The intermediate ketones were prepared by a modified Nef reaction using nitroalkenes to react with Fe-HCl.Condensation of (R)-(+)-2-methyl-2-propanesulfinamids with ketones, which was followed by a final desulfonation treatment with a solution of hydrochloride/methanol under mild conditions, optical pure (R)-sulfonamides could be synthesized.Without further chiral separation processing, the target products of (R)-l-(1H-indo1-3-yl)propan-2-amines could be obtained with higher yield and excellent enantiopurity (over 99% e.e.), thus it was time-saving and cost-saving.

关键词： (R)-1-(1H-indol-3-yl)propan-2-amines Ellmans sulfonamides ketones condensation reaction enantiopure

作者: Zhi Guang Peng Yuan Xiang Yao Dong Hong Yin Jian Fu Liu Jin Gang Yu Du Shu Huang

作者单位: Key Laboratory of Resources Chemistry of Nonferrous Metals,Ministry of Education,Central South Unive R&D Center,China Tobacco Hunan Industrial Corporation,Changsha 410014,Hunan,China Key Laboratory of Resources Chemistry of Nonferrous Metals,Ministry of Education,Central South Unive College of Science,Honghe University,Menzi 661100,Yunnan,China

会议类型: 国际会议

会议名称: 2012 China Functional Materials Technology and Industry Forum(2012中国功能材料科技与产业高层论坛)(CFMTIF2012)

会议地点: 昆明

会议语种:英文

页码: 550-553

在线出版日期: 2012-11-09（万方平台首次上网日期，不代表论文的发表时间）