Anti-Oxidant and Anti-Diabetic Effects of Mycelium and Fruit-Body Extracts of Mycoleptodonoides aitchisonii
Mycoleptodonoides aitchisonii (Berk.) Maas Geest is a culinary mushroom that is recognized as both a nutritious food and an excellent source of bioactive compounds.The purpose of this study was to investigate the antidiabetic and antioxidant properties of M.aitchisonii both in vitro and in vivo.To measure the antioxidant activity ofM.aitchisonii extracts against peroxynitrite,peroxyl radical and hydroxyl radical,scavenging activities were evaluated by total oxyradical scavenging capacity (TOSC) assays.The results revealed that fruit-body extracts had 0.9,3.7,and 1.6-fold higher activities relative to the mycelium extract.For an in vitro anti-diabetic assay,the Akt phosphorylation method was used,which is based on the signal transduction pathway of diabetes.Fruit-body extracts significantly inhibited the decrease of Akt phosphorylation by IL-6,but there was no effect from the mycelium extract on Akt phosphorylation.At a maximum fruit-body extract concentration of 100 μg/mL,the phosphorylation level of Akt increased to 77%,whereas the level was 50% for the insulin-only treatment group.M.aitchisonii treatment also resulted in a significant reduction in blood sugar and cholesterol in a streptozotocin-induced diabetic mouse.The M.aitchisonii fruit body can potentially be used to prevent various diseases such as sugar and lipid metabolism disorders.
Mycoleptodonoides aitchisonii anti-oxidant anti-diabetic Akt phosphorylation lipid metabolism medicinal mushroom fruit body
HYUN-JAE SHIN DEUK-SIL OH JONG-MIN CHOI SANG-KYUM KIM AN-JIN WI BYUNG-SUN YUN
Department of Chemical and Biochemical Engineering, Chosun University, Gwangju 501-759, South Korea Jeonnam Forest Resources Research Institute, Naju 520-833, South Korea College of Pharmacy, Chungnam National University, Daejeon 305-764, South Korea
国际会议
The 7th International Medicinal Mushroom Congerence(第七届国际药用菌大会(IMMC7)
北京
英文
220-233
2013-08-26（万方平台首次上网日期，不代表论文的发表时间）