Tissue Significances Tests on DNA Binding Sequence Motifs for Human Genes

摘要：

　　DNA binding sequence motifs are becoming increasingly important in the analysis of gene regulation,disease diagnosis and drug design.Although so far there are amount of tools available to discover these kinds of motifs,little was done to identify the biological functions,especially in tissue or cell type specific contributions,of those motifs.In this paper we used an integrated pipeline to discover sequences motifs for the promoter regions of human genes.Then we distinguished two types of motifs: tissue rich motifs (TRM) and tissue even motifs (TEM),using hypotheses test approaches including Bayesian hypothesis,Binomial distribution and traditional z-test.We finally got 233 overlapped TRMs and 56 TEMs.Most of those motifs are validated against JASPAR databases.

关键词： tissue specificity tissue rich motifs tissue even motifs and hypothesis test

作者: Hua Yu Xiu-Jun GONG

作者单位: School of Computer Science and Technology, Tianjin University, Nankai, Tianjin, China, 300072;Tianjin Key Laboratory of Cognitive Computing and Application, Tianjin, China, 300072

会议类型: 国际会议

会议名称: 7th International Conference on Systems Biology(第7届计算系统生物学国际研讨会)(ISB2013)

会议地点: 安徽黄山

会议语种:英文

页码: 39-42

在线出版日期: 2013-08-22（万方平台首次上网日期，不代表论文的发表时间）