Phytochemicals of some plants are believed to have natural anti-proliferative properties to various cancer cells.Thus,they might have the potential as alternative choice for contemporary treatment as the latter are usually associated with many unpleasant side effects.The aim of this study is to investigate the possible anti-cancer effect of aloe emodin (AE; 1,8-Dihydroxy-3-hydro-xymethyl-anthraquinone) on estrogenpositive breast cancer cells,MCF-7.We were able to demonstrate the efficiency of AE,an antraquinone derivatives which are present in Aloe Vera leaves,in limiting the proliferation effect of MCF-7 cells in a dose and time dependent manner using WST-1 assay.Our preliminary result suggests that AE could be a promising natural candidate for future pharmacological study,targeting in breast cancer prevention strategies.
Aloe Vera aloe emodin breast cancer MCF-7 cells anti-cancer WST-1
Indah Mohd Amin Siti H. Sheikh Abdul Kadir Nik Mohd Mazuan Nik Mohd Rosdy Rosfaiizah Siran Narimah A. H. Hasani
Institute for Medical Molecular Biotechnology(IMMB), Faculty of Medicine, Universiti Teknologi MARA( Institute for Medical Molecular Biotechnology(IMMB), Faculty of Medicine, Universiti Teknologi MARA( Faculty of Dentistry, Universiti Teknologi MARA(UiTM), Malaysia Department of Physiology, Faculty of Medicine, Universiti Teknologi MARA(UiTM), Malaysia Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Universiti Teknologi MARA(Ui