Construction of human tissue-specific phosphorylation networks with protein expression data
Phosphorylation is a post-translational modification process mediated by kinases through the addition of a covalently bound phosphate group,which plays important roles in a wide range of cellular progresses,such as signaling cascades and development.Over the past years,despite many phosphorylation sites have been determined with mass spectrometry techniques,it is not clear which kinase phosphorylates which proteins.Under the circumstance,we propose a new probabilistic model to identify the substrates phosphorylated by certain kinases.Furthermore,we construct three tissue-specific phosphorylation networks based on protein expression data.Investigating the constructed tissuespecific networks,we find they are functionally consistent with the corresponding tissues,implying the effectiveness and biological significance of our proposed approach.
Yin-Ying Wang Chenglei Sun Luonan Chen Xing-Ming Zhao
Institute of Systems Biology,Shanghai University,Shanghai 200444, China Key Laboratory of Systems Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sci School of Electronics and Information Engineering,Tongji University,Shanghai 201804, China
国际会议
7th International Conference on Systems Biology(第7届计算系统生物学国际研讨会)(ISB2013)
安徽黄山
英文
129-133
2013-08-22（万方平台首次上网日期，不代表论文的发表时间）