Anti-rheumatic effects of Tripterygium wilfordii Hook F in a network perspective

摘要：

　　Rheumatoid arthritis (RA) is a chronic disease that affects the joints,often those in a person’s wrists,fingers,and feet.In contrast to FDA-approved anti-RA drugs,Tripterygium wilfordii Hook F (TwHF),a traditional Chinese medicine (TCM),featured as multi-targeting,have been acknowledged with notable anti-RA effects although the pharmacology is unclear.In this work,we investigated the therapeutic mechanisms of TwHF at protein network level.First,RA-associated genes,the protein targets of FDA approved anti-RA drugs and TwHF were collected.Then we mapped the protein targets of TwHF on the drug-target network of FDA approved anti-RA drugs and KEGG RA pathway,based on these information and resources.Furthermore,we quantitatively analyzed the anti-rheumatic effect of TwHF and compared it with those of FDA approved anti-RA drugs by a network based anti-rheumatic effect score.Our study suggests that TwHF may function as a combination of disease-modifying anti-rheumatic drug and non-steroidal antiinflammatory drug and its anti-rheumatic power could be comparable with that of anti-inflammatory agents.This study may facilitate our understanding of the RA treatment by TwHF from the perspective of network systems and it may suggest new approach for the study of TCM pharmacology.

关键词： Tripterygium wilfordii Hook F Rheumatoid arthritis disease gene drug target protein-protein interaction network pathway therapeutic effect

作者: Haiyang Fang Tinghong Yang Yichuan Wang Yang Ga Yi Zhang Weidong Zhang Jing Zhao

作者单位: Department of MathematicsLogistical Engineering UniversityChongqing, China Tibet Traditional Medical CollegeLhasa, China The National Medical College Chengdu University of TCM Chengdu, China Department of Natural Medicinal ChemistrySecond Military Medical UniversityShanghai, China Department of Mathematics Logistical Engineering University Chongqing, China

会议类型: 国际会议

会议名称: 7th International Conference on Systems Biology(第7届计算系统生物学国际研讨会)(ISB2013)

会议地点: 安徽黄山

会议语种:英文

页码: 145-149

在线出版日期: 2013-08-22（万方平台首次上网日期，不代表论文的发表时间）