Improved Dynamic Analysis of Development of Pulmonary Edema
Based on the effects of proteglycans differential degradation on the mechanical properties of interstitial matrix during pulmonary edema development,we set up a dynamic lumped parameter model describing interstitial fluid flow in lung.We analyzed the effect of parameters such as the transmural driving force and the hydraulic conductivity of capillary wall,the integrity of endothelial basal membrane and basic matrix structure.The theoretical results were identical with recent physiological discoveries of interstitial macromolecular scaffold,and give a rational explanation of the development of pulmonary edema from a dynamic view,which is helpful to precaution and treatment of pulmonary edema.
Z.ZHANG
Fudan University, No.2500 Songhu Road,Shanghai,China
国际会议
Sixth International Conference on Nonlinear Mechanics(第六届国际非线性力学会议)(ICNM-VI)
上海
英文
371-376
2013-08-01（万方平台首次上网日期，不代表论文的发表时间）