Effect of Chelidonine on the expressions of Cdk1 and cyclinB1 proteins in SGC-7901 cells
To study the effect of chelidonine on Cdk1,p-Cdk1(Thr1 4),cyclinB1 protein expression in SGC-7901 Cells,and to explore the mechanism of chelidonine inducing G2/M phase arrest in SGC-7901 Cells.Western Blotting was used to study the effects of chelidonine on the Cdk1,p-Cdk1(Thr14) and cyclinBl protein expressions in SGC-7901 cells.Chelidonine could significantly decrease the expression of Cdkl and cyclinBl protein.Meanwhile,chelidonine could remarkably increase the expression of p-Cdkl(Thrl4) protein in a dose dependent manner.Chelidonine can down-regulate the expression of Cdkl,cyclinBl and up-regulate p-Cdk1 (Thr14) protein expression in SGC-7901 cells,which may be one of the role mechanism of G2/M phase arrest induced by chelidonine in SGC-7901 cells which may be one of the role mechanism of G2/M phase arrest induced by chelidonine in SGC-7901 Cells.
chelidonine Cdk1 p-Cdk(Thr14) cyclinB1 human gastric carcinoma SGC-7901 cells
Zhong-yuan QU Xiang ZOU Jing-wen ZHAO Yu-bin JI
School of Pharmacy,Harbin University of Commerce,Harbin 150076,China Engineering Research Center of Natural Anticancer Drugs,Ministry of Education,Harbin University of C Engineering Research Center of Natural Anticancer Drugs,Ministry of Education,Harbin University of C
国际会议
西安
英文
36-39
2013-07-27（万方平台首次上网日期，不代表论文的发表时间）