Mitotic catastrophe induced by Chelidonine on human gastric carcinoma SGC-7901 cells

摘要：

　　To study the mitotic catastrophe induction effect of chelidonine on human gastric carcinoma SGC-7901 cells,MTT assay was applied to detect the proliferation inhibition effect of chelidonine.Giemsa staining was used to observe the morphological changes of the nucleus in gastric cancer cells and mitotic index(MI) was calculated.The results showed that chelidonine could effectively inhibit the proliferation of SGC-7901 cells and the IC50 was 48.67μmol/L.After treatment with 6.25-25μmol/L chelidonine,the numbers of giant cells with two or more nuclei was increased along with the increase of drug concentration.The mitotic index of cells was significantly increased compared with that of the control group(P<0.01).The conclusion can be drawn that chelidonine can inhibit the proliferation of SGC-7901 cells by inducing mitotic catastrophe of gastric carcinoma cells.

关键词： chelidonine Mitotic catastrophe human gastric carcinoma SGC-7901 cells

作者: Zhong-yuan QU Xiang ZOU Jing-wen ZHAO Yu-bin JI

作者单位: School of Pharmacy,Harbin University of Commerce,Harbin 150076,China Engineering Research Center of Natural Anticancer Drugs,Ministry of Education,Harbin University of C Engineering Research Center of Natural Anticancer Drugs,Ministry of Education,Harbin University of C

会议类型: 国际会议

会议名称: 2013 International Conference on Advanced Engineering Materials and Architecture Sciences(2013先进工程材料与建筑科学国际会议)(ICAEMAS 2013)

会议地点: 西安

会议语种:英文

页码: 99-102

在线出版日期: 2013-07-27（万方平台首次上网日期，不代表论文的发表时间）