Effect of Three Major Polyphenols in Red Wine on Sodium Channel Current in Mouse Dorsal Root Ganglia Cells
(0) It has been reported that polyphenols in red wine have potentially protective effects such as vasodilation,lowering blood pressure,reduction of endothelin synthesis,antioxidation,anticancer effects,and inhibition ofkinases,whereas the precise mechanism underlying the polyphenol effects remains obscure.In this study,patch-clamp test was employed in order to examine the effect of three major polyphenols,quercetin,resveratrol,and catechin,extracted from red wine on sodium channel currents in mouse dorsal root ganglia cells.The three polyphenols more or less suppressed the sodium channel activity in a concentration-dependent manner.This suggests the sedative impact of polyphenols on the neuronal excitation.
polyphenols Na+-channel currents neuronal cells
Yan-Ling Wu Yan-Ping Ding Yoshimasa Tanaka
Virus Inspection Department of Zhejiang Provincial Center for Disease Control and Prevention,630 Xin Center for Innovation in Immunoregulative Technology and Therapeutics,Graduate School of Medicine,Ky
国际会议
西安
英文
126-130
2013-07-27（万方平台首次上网日期，不代表论文的发表时间）