Effects of sulfur dioxide and its derivatives on the functions of rat hearts and their mechanisms

摘要：

　　The present study was designed to investigate the mechanisms underlying the effects of SO2 on functions of the isolated perfused hearts in rats.The results suggest that both SO2 and SO2 derivatives (sulfite:bisulfite,3:1,M/M) elicited a negative inotropic effect.At high concentrations,the effects of SO2 or its derivatives on heart functions might be related to the increasing of reactive oxygen species (ROS) contents and decreasing of ATPase activities as well as the potentially damaging effects on the hearts; while at low concentrations,SO2 or its derivatives might modulate heart functions mainly through the NO signal transduction pathway.

关键词： sulfur dioxide SO2 derivatives heart function inotropic effect

作者: Quanxi Zhang Jingjing Tian Yunlong Bai Zhenhua Yang Huifang Zhang Ziqiang Meng

作者单位: Institute of Environmental Medicine and Toxicology, Research Center of Environmental Science and Eng China Institute for Radiation Protection, Xuefu Street 102＃, Taiyuan 030006, China

会议类型: 国际会议

会议名称: 2013 International Symposium on Environmental Science and Technology(2013环境科学与技术国际会议)

会议地点: 大连

会议语种:英文

页码: 32-37

在线出版日期: 2013-06-04（万方平台首次上网日期，不代表论文的发表时间）