Keeping toxicology abreast of technology of engineered metallic nanoparticles

摘要：

　　Metallic nanoparticles include both elemental metallic nanoparticles and metal oxide nanoparticles.Metallic nanoparticles are believed to be the basis of many of the future technological and biomedical innovations of this century.However,it has been shown recently that many of nano-sized particles of these materials,not their macro or micro counterparts,are toxic to living organisms.Thus,there is an urgent need to develop rapid,accurate and efficient testing strategies to assess the potemial hazard of these emerging materials.Prevention is always the best strategy to minimize human or environmental exposure to hazardous nanomaterials.Early identification of the potentially hazardous properties of nanomaterials could enable us to design or redesign these materials with less health impact while retaining the main desirable properties.The objectives of this review are to provide an overview on the relationship between individual physicochemical parameters and biological response after exposure to engineered elemental metallic nanoparticles (with focus on gold and silver) and metal oxide nanoparticles.Possible mechanisms of observed toxicity,influence of biotic and abiotic factors on particles toxicity,and different biological models (in vitro and in vivo) for studying nanotoxicity are discussed.Doped metal oxide nanoparticles,new designer products in the recent development of safe nanotechnology application,are also reviewed.Finally,a brief discussion on research gaps and collaboration needed in nano ecotoxicity studies is provided.

关键词： Nanoparticles Toxicology Metallic Metal oxide

作者: Huey-Min Hwang Paresh Ray Hongtao Yu Xiaojia He

作者单位: Jackson State University, Department of Biology, Box 18540, 1400 Lynch Street, Jackson, MS 39217, U. Jackson State University, Department of Chemistry and Biochemistry, Box 17910, 1400 Lynch Street, Ja

会议类型: 国际会议

会议名称: 2013 International Symposium on Environmental Science and Technology(2013环境科学与技术国际会议)

会议地点: 大连

会议语种:英文

页码: 81-85

在线出版日期: 2013-06-04（万方平台首次上网日期，不代表论文的发表时间）