Exploring the control of toxicity from nanoparticles and the adsorbed pollutant
Nanomaterials are widely used in various industrial sectors,biomedicine,and more than 1300 consumer products.Although there is still no safety regulation,their potential toxicity is a major concern worldwide.These nanomaterials adsorb environmental pollutants such as heavy metal ions and cause even more serious damages to human.We discovered that carbon nanotubes enter human cells,perturb cellular signaling pathways,affect various cell functions,and cause malfunctions in animals.Toxicity from carcinogenic Cr (Ⅵ) may be partially alleviated by nanoparticles.Because the majority of atoms in a nano-sized particle are on the surface,chemistry modification on its surface may change its biological properties significantly.To prove this hypothesis,we modified nanoparticle surface using a nano-combinatorial chemistry approach.Novel nanoparticles were discovered to have a reduced toxicity,an enhanced cancer targeting ability,or an increased cell differentiation regulation.Quantitative nanostructure-activity relationships (QNAR)models have been built and applied for virtual screening of a library collection of 240,000 ligands potentially attachable to CNT.Toxic and nontoxic CNTs decorated by selected ligands prioritized by QNAR model-based virtual screening were synthesized and tested.An 85% success rate was achieved.
Bing Yan
School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P.R.China
国际会议
2013 International Symposium on Environmental Science and Technology(2013环境科学与技术国际会议)
大连
英文
775-775
2013-06-04（万方平台首次上网日期，不代表论文的发表时间）