Endocrine Regulation and Mechanisms of Colostrogenesis
Colostrum formation is important for the newborn.For the ruminant calf,it becomes critical for the reduction in risk of intestinal disease such as scours.Because in utero transport of immunoglobulins does (IgG) not occur through the ruminant placenta,a calf needs to obtain adequate mass of this IgG orally from the colostrum.A major problem with obtaining this protection is that dairy cow production of quality colostrum is very erratic.While some research has been conducted on colostrogenesis,the knowledge of the cellular process is rather unknown.It is likely that the transfer of IgG from the maternal blood through the cell and into the secretions occurs through a protein complex termed FcRn.We and others have shown mammary expression of this gene and recently we showed that it is regulated by steroids.Compartmental analysis of previously published kinetic analysis of IgG1 turnover in cow matemal blood during colostrogenesis indicates that another process occurs with this same FcRn complex that is termed recycling.This process accounts for the long half life of circulating IgG.Aspects of colostrums formation will be discussed relative the the FcRn.
Mammary Colostrum FcRn transcytosis IgG1
C.Baumrucker R.Bruckmaier
Penn State University, Dept.Animal Science, University Park, PA, USA Veterinary Physiology, Vetsuisse Faculty, University of Bern, Switzerland
国际会议
3rd International Symposium on Dairy Cow Nutrition and Milk Quality(第三届“奶牛营养与牛奶质量国际研讨会)
北京
英文
71-79
2013-05-11（万方平台首次上网日期，不代表论文的发表时间）