Skin and Subcutaneous Lesions Induced by Application of Para-phenylenediamine in Rabbits
para-phenylenediamine (PPD)is a black dye used in permanent oxidative hair dyes.It is a major cause of allergic contact dermatitis.So these studies were designed to confirm this effect on the skin.18 adult domestic rahbits were divided into three groups,first group used as control,second group painted with PPD in a conc.of 2%.Third group painted with PPD (2% )and administered antox (2 mg/animal/day)in the diet as antioxidant.PPD applied twice weekly for 6 months.The results were areas of alopecia,necrosis of skin,sensitization of skin (patchy hyperemia).Histopathological sections revealed sever dermatitis with infilteration of the dermis with a great number of eosinophils,Folliculitis and perifollculitis were also seen.Tubulonephritis,myocarditis and rhahdomyolysis was also reported.leukocytosis with prominent eosinophilia in the hlood.In the third group antox did not protect the skin of rabhits from the deleterious toxic effect of PPD.From these results we can concluded that PPD was associated with allergic contact dermatitis,its toxic effect extend to circulation and internal organs so strict control of its practical uses should be adopted.
para-phenylenediamine allergic contact dermatitis rabbits
Mahmoud A.Z Allam Nafady Mohamed H.Kotob
Department of Pathology,Faculty of Veterinary Medicine,Assiut University,Assiut,Egypt
国际会议
XVIth International Congress on Animal Hygiene(第十六届动物卫生国际会议(ISAH 2013))
南京
英文
151-153
2013-05-05（万方平台首次上网日期，不代表论文的发表时间）