Chronic Toxicity Study of Injection Drug for the Treatment and Prevention of Liver Disease in Animals
This paper deals with the study of chronic injectable drug for the treatment and prevention of liver disease in animals and study the possibility of using it for complex treatment of liver pathologies.Chronic toxicity was studied in 18 white male mice with an initial mass of 20-25,all the animals were divided into 3 groups of 6 animals each.The animals of the experimental group 1 intramuscularly daily for 1 month study medication was administered at a dose of 10 mg/kg for the active substance or 0.8 ml/kg (concentration of active ingredient in the drug was 12 mg/ml),which corresponded to 50 1/10LD 2 the second group-1mg/kg of the active ingredient,or 0.4 ml/kg (concentration of active ingredient in the drug was 2.4 mg/ml),corresponding t0 1/100 of the LD50.Control animals,under the same conditions and feeding were administered an equal volume of a solution of excipients included in the formulation without the active ingredient at the rate of 0.8 ml/kg of the drug with no active ingredient.
Volkov A.A Staroverov S.A Putina S.N Bashkirova E.V Sazykina K.I
Saratov State Agrarian University N.I.Vavilov The Institute for Biochemistry and Physiology of plants and microorganisms(The Department of the Rus
国际会议
XVIth International Congress on Animal Hygiene(第十六届动物卫生国际会议(ISAH 2013))
南京
英文
227-227
2013-05-05（万方平台首次上网日期，不代表论文的发表时间）