Role of Anti-oxidants in Reducing Aflatoxicosis in Chickens
Mycotoxicoses are diseases caused by consumption of diets contaminated with mycotoxins,a special class of fungal secondary metabolites.Aflatoxin B1 (AFB1)and Fumonisin B1 (FB1)are the main toxins synthesized by toxicogenic stocks of Aspergillus spp.and Fusarium spp.respectively and can coexist in grains and in its by-products.The other types of mycotoxins are ochratoxins,patulin,trichothecenes and zearalenone).they all represent the main problems for human and animal health in the world.Aflatoxins can enter the food chain through contaminated cereals and foods (e.g.,milk,meat.and eggs)obtained from animals fed aflatoxin-contaminated feeds.Aflatoxins (AF)have a high impact in both human and animal health,causing significant economic losses in the poultry industry,especially by diminution of avian growth,feed efficiency,and product quality.Aflatoxins affect the whole organism,particularly liver and kidney.Mycotoxins chemical,biological,and toxicological properties are diverse.Hence,their toxic effects are extreruely variable,depending on the intake level.duration of exposure,anirual species,age,sex,physiological status,and eventual synergism between mycotoxins simultaneously present in feed or foods.However,the main toxic effects for aflatoxicosis,oxidative stress is a common mechanism contributing to initiation and progression of hepatic damage.When animals or humans consume these foods,AFB,is metabolized in the liver producing the formation of highly reactive chemical intermediaries.Because lipid peroxidation plays a major role in the toxicity of AF,a protective effect of antioxidants is possible.Antioxidants like vitamins (E,A and C),carotenoids,selenium and other antioxidants material have inhibitory action on biotransformation of AF to their active epoxide derivatives,and have beneficial effects in ameliorating the adverse effects resulting from AF.
El-Deep,M.H Daichi,IJIRI Akira,OHTSUKA
Animal Prod,Inst,Agric,Res,Center,Ministry of Agric,Egypt;Department of Biochemical Sciences and Bio Department of Biochemical Sciences and Biotechnology,Faculty of Agriculture,Kagoshima University,Jap
国际会议
XVIth International Congress on Animal Hygiene(第十六届动物卫生国际会议(ISAH 2013))
南京
英文
309-312
2013-05-05（万方平台首次上网日期，不代表论文的发表时间）