Intestinal Immunity of Escherichia coli Nissle 1917:Safe Vehicles for Targeted Therapeutics

摘要：

　　The probiotics E.coli Nissle 1917 has been widely used in medicine and cattle production industry.Escherichia coli strain Nissle 1917 is a non-pathogenic fecal isolate,combining both the excellent colonization properties and its non-immunogenic character.and can be administrated orally.Genetically modified probiotics can very well be an ideal candidate as carrier organism for gut-focused in situ synthesis and expression of specific localized antigen delivery into the intestine.And for the first time,a live genetically modified bacterial strain has been approved by Dutch authorities as a therapeutic agent for experimental therapy of intestinal bowel disease (IBD)in humans.

作者: Xia Pengpeng

作者单位: College of Veterinary Medicine,Yangzhou University,Yangzhou 225009,China;Ministry of Education Key Lab for Avian Preventive Medicine,Yangzhou 225009,China

会议类型: 国际会议

会议名称: XVIth International Congress on Animal Hygiene(第十六届动物卫生国际会议(ISAH 2013))

会议地点: 南京

会议语种:英文

页码: 351-351

在线出版日期: 2013-05-05（万方平台首次上网日期，不代表论文的发表时间）