Expression of CYPIA1,CYP2E1 and CYP3A1 in SudanⅠ-Induced Hepatic Injury

摘要：

　　To disscuss the effect of sudanⅠexpressions of CYPIA1,CYP2E1 and CYP3A1 in Rat Liver,the experiment is the detection of enzymatic activity,half-quantitative analysis of RT-PCR.Experimental and real-time PCR examination.Animal were randomly divided into two group: control group,sudan Ⅰ group,The sudan Ⅰ group was divided into four does group.Liver and blood were collected for test 10 days after treatment.These results indicated that CYPIA1,CYP2E1 and CYP3A1 gene were mcrease in a certain dose range,compared with control group,the activity of CYP2E1,CYP3A1 in Rat Liver Microsome were mcrease in a certain dose range,compared with control group.This result point out that sudanⅠimpacted the activity and expression of CYPIA1,CYP2E1 and CYP3A1,educed various kinds poisoning effects,leaded to the poisoning of organism and injury of Rat Liver.

作者: Zang Yating Li Xiangfeng Lu Qin Cui Yanyan Wang Weina Xie Lijun Niu Xin Wang Xia Liu Haifeng Gao Hong Zhao Ru Yan Yulin Jiang Huan Huang Hui Chen Gang Shao Zhiyong

作者单位: College of Animal Science and Technology,Yunnan Agricultural University,Kunming 650201,China

会议类型: 国际会议

会议名称: XVIth International Congress on Animal Hygiene(第十六届动物卫生国际会议(ISAH 2013))

会议地点: 南京

会议语种:英文

页码: 495-497

在线出版日期: 2013-05-05（万方平台首次上网日期，不代表论文的发表时间）