Investigation of the Expression and Subcelluar Locolization of αB-Crystallin and HSF-1 in Rat Primary Myocardial Cells Subjected to Heat Stress

摘要：

　　The aim of this study is to investigate the role of aB-crystallin and Heat shock factor-1 (HSF-1)in cell protection under heat stress at 42℃.According to our experiment,it appears that HSF-1 stimulated an increase in αB-crystallin transcription following exposure to heat stress in rat myocardial cells.However,the levels of the αB-crystallin protein did not correlate with the increase in mRNA levels,suggesting discordance between transcription and translation.These findings may suggest that the consumption of αB-crystallin exceeded its production in myocardial cells after a short duration of heat stress.Sufficient levels of αB-crystallin to maintain normal cellular functions were restored after the heat stress had ceased.

作者: Tang Shu Bao Endong Buriro Rehana Liu Zhijun Zhang Miao Ali Islam Mohammad Abdel Nasir Cheng Yanfen Chen Hongbo Hartung J

作者单位: College of Veterinary Medicine,Nanjing Agricultural University,Nanjing 210095,China Institute for Animal Hygiene,Animal Welfare and Farm Animal Behaviour,University of Veterinary Medic

会议类型: 国际会议

会议名称: XVIth International Congress on Animal Hygiene(第十六届动物卫生国际会议(ISAH 2013))

会议地点: 南京

会议语种:英文

页码: 513-516

在线出版日期: 2013-05-05（万方平台首次上网日期，不代表论文的发表时间）