Toxoplasma gondii:Efficacy of an Irradiated Vaccine Against Experimental Infection Challenge in Wistar Female Rats
Toxoplasmosis is a worldwide zoonotic disease caused by Toxoplasma gondii(T.gondii)protozoa.It causes economic losses in livestock production and also serious implications on Public Health.due severe neurological and reproductive symptoms.Prevention measures for T.gondii infections block have not been reached in order to avoid toxoplasmosis occurrence.The development of anti-T.gondii vaccines may be an important alternative for the disease control.The objective of the present study was to evaluate the efficacy of a T.gondii tachizoites irradiated vaccine,administered in experimentally inoculated Wistar female rats,aiming to block the production of T.gondii cysts in brain and muscle tissues,and also the congenital transmission.It was verified that the immunization with irradiated tachyzoites of T.gondii induced the reduction of parasitic load in most organs analyzed,although not prevent the establishment of infection with the parasite.And also,the immunization showed a favorable effect on the birth rate and litters size.
Troncarelli,M.Z Camossi,L.G Fornazari,F.I Richini-Pereira.V.B Silva,R.C Langoni,H
Faculty of Veterinary Medicine and Animal Science,ESP Botucatu-SP,Brazil Instituto Adolpho Lutz,Bauru-SP,Brazil
国际会议
XVIth International Congress on Animal Hygiene(第十六届动物卫生国际会议(ISAH 2013))
南京
英文
578-580
2013-05-05（万方平台首次上网日期，不代表论文的发表时间）