State-space Model for Estimating Acupuncture Spike Firing Rate

摘要：

　　In order to reveal the underlying mechanisms about the conduction of acupuncture signal,manual acupuncture (MA) manipulations with different frequencies are taken at ‘Zusanli’ points of experimental rats.The induced spike series in spinal cord dorsal horn is detected and recorded.Consider spike series as point process,it is found that rate coding features of acupuncture with different frequencies are different.To elucidate the underlying mechanisms,we develop a state-space model for estimating the spike firing rate function by maximum likelihood using an approximate Expectation-Maximization (EM) algorithm.Model goodness-of-fit assessment,confidence intervals for the spike firing rate function are also given.It is shown that this model could accurately characterize acupuncture spike firing rate.The underlying mechanisms of acupuncture are better understood from the perspective of state-space by combining the simulation results.

关键词： Acupuncture Zusanli Spike sorting State-space model Spike firing rate

作者: Jiang Wang Xue Wang Ming Xue Bin Deng Xile Wei Chunxiao Han

作者单位: School of Electrical and automation engineering, Tianjin University, Tianjin 300072

会议类型: 国际会议

会议名称: the 25th Chinese Control and Decision Conference(第25届中国控制与决策会议)

会议地点: 贵阳

会议语种:英文

页码: 4430-4434

在线出版日期: 2013-05-01（万方平台首次上网日期，不代表论文的发表时间）